In vivo and in vitroevaluation of the Acrocomia aculeatapulp oil - lipid profile and oxidative stress

Authors

  • Ana Cristina Jacobowski Protein Purification Laboratory and their Biological Functions - Center for Biological and Health Sciences / Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil;
  • Ana Laura Colin-Gonzalez Laboratory of Excitatory Amino Acids- National Institute of Neurology and Neurosurgery; Mexico City, Mexico
  • Ariana Lizbeth Paz-Loyola Laboratory of Excitatory Amino Acids- National Institute of Neurology and Neurosurgery; Mexico City, Mexico
  • Abel Santamaria Laboratory of Excitatory Amino Acids- National Institute of Neurology and Neurosurgery; Mexico City, Mexico
  • Maria LigiaRodrigues Macedo Protein Purification Laboratory and their Biological Functions - Center for Biological and Health Sciences / Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil;

DOI:

https://doi.org/10.24297/jab.v8i3.6531

Keywords:

Acrocomia aculeata, Hypercaloric diet, Monounsaturated fatty acid, Oleic acid, Obesity, Oxidative stress, Brain synaptosomes

Abstract

Acrocomia aculeata is a plant species with high levels of antioxidant compounds, rich in carotenoids with high bioavailability and monounsaturated fatty acids. This study was designed to investigate the biological effect of Acrocomia aculeata pulp oil (AaPO) on body weight, epididymal adipose tissue mass, liver weight and blood analytes of high-fat-diet-induced obeseC57BL/6j mice.In addition, the antioxidant properties of AaPO were evaluated against the iron sulfate (FeSO4)-induced oxidativedamage to rat brain synaptosomes. Obese mice receiving oral gavage with AaPO showed a significant decrease in body weight, adipose tissue weight,plasma triacylglycerol and aspartate aminotransferase. Histological analysis showed that AaPO attenuated high-fat-diet-induced liver injury decreasing hepatic steatosis and adipocyte hyperplasia. In addition, the in vitro assays showed that AaPOprevented the FeSO4-induced oxidative damage in synaptosomal fractions. Results from this study suggest that AaPO can reduce body weight, plasma triacylglycerol, adipose tissue and oxidative stress.

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Published

2016-01-25

How to Cite

Jacobowski, A. C., Colin-Gonzalez, A. L., Paz-Loyola, A. L., Santamaria, A., & Macedo, M. L. (2016). In vivo and in vitroevaluation of the Acrocomia aculeatapulp oil - lipid profile and oxidative stress. JOURNAL OF ADVANCES IN BIOLOGY, 8(3), 1676–1684. https://doi.org/10.24297/jab.v8i3.6531

Issue

Vol. 8 No. 3 (2015)

Section

Articles

License

Creative Commons License All articles published in Journal of Advances in Linguistics are licensed under a Creative Commons Attribution 4.0 International License.