EVALUATION OF THE ANTICANDIDOSIC ACTIVITY OF THE CRUDE AQUEOUS AND ETHANOLIC EXTRACT OF EUCALYPTUS SP, A MYRTACEE FROM THE IVORIAN PHARMACOPEIA ON THE IN VITRO GROWTH OF CANDIDA ALBICANS, CANDIDA GLABRATA and CANDIDA TROPICALIS

Abstract

With the advent of AIDS/ HIV, we assist to a trong new outbreak of thrive's mycoses. To fight against this mycoses apparition, our research team has tested the whole crude extracts action (water and hydro-alcoholic), outlet from husks of Eucalyptus sp a Myrtaceae on the in vitro growth of Candida albicans, Candida glabrata, and Candida tropicalis. Extracts incorporation to the sabouraud's geloses has been made according to double dilution method with in slope tube. After 48 hours of incubation at 30°C, these extract exhibited anticandidosic activity in dose-response relationship. The hydro- alcoholic extract is the most active extract on in vitro growth three clinical isolate of Candida, with the following antifungal parameters (C. albicans FMC = 250 μg/mL, IC50 = 14.57 μg/mL, C. glabrata FMC = 250 μg/mL, IC50 = 11.90 μg/mL, C. tropicalis FMC = 250 μg/mL, IC50 = 11.15 μg/mL). The crude extracts of Eucalyptus sp tested showed anticandidosic activity and this activity was more pronounced with hydro-alcoholic extract.